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An experimental drug is able to rapidly improve the symptoms of depression in people who haven't responded to previous therapies, although the benefits are short-lived, a new study says.
People who took the experimental drug, known as AZD6765, showed improvements in their depression symptoms after just one hour and 20 minutes compared with those who took a placebo. This effect lasted for about 30 minutes, and some patients continued to see a benefit up to two days after treatment.?
On average, participants in the study had previously tried and failed seven rounds of treatment with various antidepressant therapies. Nearly half had failed to respond to electroconvulsive therapy (ECT), also known as "shock therapy."
Fast-acting drugs for major depression are urgently needed, said study researcher Dr. Carlos Zarate, of the National Institute of Mental Health. Current antidepressants typically take several weeks to start working, which can jeopardize a depressed person's health, particularly if he or she is at risk for suicide.
Another drug, calledketamine, has recently been shown to ease depression symptoms within hours, but its use has been limited because of serious side effects, including hallucinations. Ketaminehas also been used as a sedative and as a recreational drug.
The new findings suggest that researchers could potentially create a drug that works just as quickly as ketamine, but without the dangerous side effects, Zarate said.No harmful effects from AZD6765were seen during the study.
However, further research is needed to test whether different doses of the drug can produce more long-lasting effects, Zarate said.
Fast-acting therapies
Many antidepressants work by increasing levels of a brain chemical called serotonin, which is linked to mood. But ketamineand the experimental drug work a different way ? they prevent the binding of a brain chemical called glutamate to nerve cells. Glutamate is also involved in mood regulation, Zarate said.
In the new study, half of the participants took AZD6765, which is given through an intravenous solution (IV), and half took a placebo. All participants filled out a survey assessing their level of depression immediately after taking the drug, and a few days after treatment. A week later, the groups switched the agent they took, so that everyone received the drug at some point during the study.
Overall, about one-third of the participants responded to the treatment ? meaning they experienced at least a 50 percent reduction in their depressive symptoms during the study ? compared with a 15 percent reduction in those who took the placebo.
The main side effects AZD6765 were headache, nausea and some problems concentrating, Zarate said. Patients did not have "out of body" experiences, which have been reported as a side effect of ketamine.
New treatments
"It's been well over two decades since we've had any major breakthroughs," in drug treatments for depression, said Steven Hollon, a? professor of psychiatry at Vanderbilt University in Nashville, who was not involved in the study. "Anything that can produce a rapid response in a refractory patient population has got real potential to help down the line."
The new drug may not produce serious side effects because it does not block glutamate binding as completely as ketamine does.
However, the new drug does not appear to work quite as well as ketamine. In a previous study, more than half of patients who took ketamine responded within an hour and 20 minutes (compared with 27 percent for AZD6765), and the antidepressant effects lasted for seven days.
Future studies may test higher or more frequent doses of the drug, or perhaps the drug can be developed as an oral form, Zarate said. Researchers may also test new drugs that target the glutamate system, he said.
The study was funded by the National Institutes of Health. The pharmaceutical company AstraZeneca owns a patent on AZD6765, and provided the study drug. One of the study authors works for AstraZeneca.
Pass it on: A new drug provides fast relief for depression symptoms, but so far, the effects are short-lived.
Follow Rachael Rettner on Twitter @RachaelRettner, or MyHealthNewsDaily @MyHealth_MHND. We're also on Facebook & Google+.
Copyright 2012 MyHealthNewsDaily, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/fast-acting-depression-drug-eases-symptoms-hours-210713821.html
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Fiscal cliff talks have stalled as 'serious differences' remain between both parties ? and according to the latest NBC/WSJ poll the public wants an agreement, soon. Although both sides are still discussing ways to avoid the fiscal cliff, neither side is optimistic that they'll come to a resolution before Christmas. NBC's Chuck Todd reports.
By NBC?s Mark Murray
An overwhelming majority of Americans want Congress and the Obama White House to reach a deal featuring both tax increases and spending cuts to avert the so-called fiscal cliff, according to the latest national NBC News/Wall Street Journal poll.
Click here for full results from the NBC News/Wall Street Journal poll (pdf)
In fact, majorities of Democrats, Republicans and political independents each support such a deal.
Yet respondents are split over whether any kind of agreement can be reached, and nearly seven in 10 believe that the coming year will feature Democrats and Republicans in Congress showing little willingness to come to an agreement on important matters.
Democratic pollster Peter D. Hart, who conducted the survey with Republican pollster Bill McInturff, says the public is sending this one-word message to Washington: compromise.
?Doing something trumps doing nothing,? Hart said.

Chip Somodevilla / Getty Images
Speaker of the House John Boehner (R-OH) talks with reporters after the weekly House GOP caucus meeting at the U.S. Capitol December 12, 2012 in Washington, DC.
Related:?Boehner: 'Serious differences' separate GOP from Obama
The survey ? conducted a month after November?s election ? also shows a positive uptick in opinion toward President Barack Obama, and more negative views about defeated GOP presidential nominee Mitt Romney and the Republican Party. The poll also finds that a majority of Americans now support gay marriage.
?Hints of a thaw?
According to the poll, a combined 68 percent of Americans say that the fiscal cliff ? the looming combination of tax increases and spending cuts set to take place at the beginning of next year if nothing is done ? is either a ?very serious? or ?fairly serious? problem.
A similar two-thirds of respondents are willing to accept an increase in taxes or cuts in federal government programs they care about to reach an agreement to avoid the problem.
Asked another way, 65 percent say leaders in Congress should find a compromise to reduce the budget deficit, even if that means Democrats would need to accept targeted spending cuts to Social Security and Medicare, and that Republicans would need to accept targeted increases in tax rates.
NBC's Mark Murray and Domenico Montanaro discuss the latest developments in the fiscal negotiations between President Obama and House Speaker John Boehner.
By comparison, just 28 percent believe that leaders should stick to their traditional positions on the deficit ? even if that means Congress goes over the fiscal cliff, triggering those automatic spending cuts and tax increases.
?There are hints of a thaw here, compared to previous data we?ve seen,? McInturff says.
Indeed, for the first time in the poll, a majority of Republicans (59 percent) want GOP leaders in the House and Senate to make compromises in order to gain consensus in the current budget debate.
Previously, in 2011, majorities of Republicans said they preferred GOP leaders to stick to their positions rather than make compromises.
And the percentage of Democrats who favor compromise on this question (70 percent) is now at an all-time high in the survey.
With Christmas less than two weeks away, the White House is faced with the same key question ? Can House Speaker John Boehner deliver enough Republican votes for whatever debt deal he and President Barack Obama agree on. The Daily Rundown's Chuck Todd reports.
Who?s to blame if there isn?t a deal? Everyone
Yet the public is split ? 48 percent of respondents are optimistic, and 48 percent are pessimistic ? over whether Congress will be able to reach consensus to avoid the fiscal cliff. And another 69 percent believe that the next year on Capitol Hill will be marked by division and little willingness to compromise.
If there is no compromise on the fiscal cliff and the automatic tax increases and spending cuts go into effect at the beginning of next year, 24 percent say they will blame congressional Republicans more, while 19 percent will point the finger at Obama and congressional Democrats.
But a majority of respondents (56 percent) say they?ll blame both sides equally.
Still, twice as many Americans say they trust the president more in handling this fiscal situation (38 percent) than House Speaker John Boehner and the congressional Republicans (19 percent).
And significant majorities believe Obama holds a clear mandate from the election on issues related to this subject:
Obama?s lift vs. the GOP?s decline
Speaking of Obama, the poll shows an uptick in his numbers after his victory in last month?s presidential election.
Fifty-three percent of adults approve of his overall job performance, and 49 percent approve of his handling of the economy ? higher marks on these questions than at any time during the 2012 campaign.
Another 53 percent say they feel either ?optimistic and confident? or ?satisfied and hopeful? Obama will do a good job as president, which is up three points from Oct. 2012.
?Any president has a little bit of a lift heading into the first few months of any new term in office,? McInturff, the GOP pollster, says.
Thursday's "Gaggle" which includes Jackie Kucinich, Margie Omero, Perry Bacon and Bob Costa talk about the fiscal cliff negotiations.
But if Obama is getting a lift after the election, the Republican Party is seeing a further decline.
The GOP?s favorable/unfavorable rating in the poll now stands at 30 percent/45 percent (minus-15 points), which is down from 36 percent/43 percent (minus-7) right before the election.
That?s compared with the Democratic Party?s 44 percent/35 percent rating (plus-9 points).
What?s more, asked to give a word or short phrase to describe the Republican Party, 65 percent offered a negative comment, including more than half of Republicans.
Some of the responses: ?Bad,? ?weak,? ?negative,? ?uncompromising,? ?need to work together,? ?broken,? ?disorganized? and ?lost.?
By contrast, 37 percent gave negative descriptions of the Democratic Party, while 35 percent were positive.
?Republicans have gone off the image cliff,? says Hart, the Democratic pollster.
?Elections have consequences,? McInturff adds about the GOP. ?And among those consequences is the cost of losing.?
The consequences of losing also exist for Romney, whom Obama defeated in November.
Romney?s favorable/unfavorable rating in the poll is 35 percent/44 percent (minus-9 points), down from his 43 percent/44 percent score (minus-1) before the election. Much of that drop comes from Republicans and conservatives.?
Majority supports same-sex marriage
Finally, for the first time ever in the NBC/WSJ poll, a majority of respondents ? 51 percent ? support same-sex marriage.
That percentage in support is up from 30 percent in 2004, 41 percent in 2009 and 49 percent in March 2012, demonstrating how quickly public opinion on this issue has changed in just eight years.
The NBC/WSJ poll was conducted Dec. 6-9 of 1,000 adults (including 300 cell phone-only respondents), and it has an overall margin of error of plus-minus 3.1 percentage points.
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